ALTERED EXPRESSION OF VITAMIN D METABOLISM GENES AND CIRCULATING MICRORNAS IN PBMCS OF PATIENTS WITH TYPE 1 DIABETES: THEIR ASSOCIATION WITH VITAMIN D STATUS AND ONGOING ISLET AUTOIMMUNITY

Background: The immunomodulatory role of 1,25-Dihydroxy vitamin D3 (1,25(OH)2D3) is exerted through its interaction with the vitamin D receptor (VDR) present on pancreatic and immune cells.While a deficiency in vitamin D has been linked to Type 1 Diabetes Mellitus (T1DM), the exact molecular mechanism driving this down-regulation in T1DM is yet to

ABSTRACT:This paper presents a review of the techniques used to reduce aerodynamic drag over bluff bodies such as cylinders, spheres, 2D bodies with blunt backs and their application to commercial road vehicles.The recent research carried out on the drag reduction is presented and categorised.A new classification of the techniques is introduced and

The most common method of cancer treatment still includes surgical treatment, which is also the oldest way to fight cancer.Radiotherapy is currently one of the basic method of treating malignant tumors [1].This method uses the action of ionizing radiation.However, the radiation does not work selectively and also damages healthy tissues.Chemotherapy

By drawing analogies with independent research areas, we propose an unorthodox framework for mapping microfinance credit risk--a major obstacle to the sustainability of lenders outreaching to the poor.Specifically, using the elements of network theory, we constructed an jumpers agent-based model that obeys the stylized rules of microfinance industr

This paper proposes a hybrid approach that integrates fuzzy multi-criteria decision-making with multi-objective mathematical optimization to address the investment management problem in the Iranian capital market under interval uncertainty.To achieve this, we first employ the fuzzy SWARA method to assess the global importance of the criteria weight